Risk Calculator 4 + DRE assessment
provides additional information, without the necessity of TRUS, for assessing men who
have previously been screened, whether or not they have had a prior biopsy; also
predicts the chance of a positive outcome and whether that would be high grade or advanced.

Rectal examination
(DRE)
DRE volume cc
PSA (ng/ml)
Previous negative biopsy (yes/no)